1.0Sydney Gastroenterologyhttps://sydneygi.com.auinfo@sydneygi.com.auhttps://sydneygi.com.au/author/infosydneygi-com-au/Whole genomes redefine the mutational landscape of pancreatic cancer. - Sydney Gastroenterologyrich600338<blockquote class="wp-embedded-content"><a href="https://sydneygi.com.au/whole-genomes-redefine-mutational-landscape-pancreatic-cancer/">Whole genomes redefine the mutational landscape of pancreatic cancer.</a></blockquote>
<script type='text/javascript'>
<!--//--><![CDATA[//><!--
/**
* WordPress inline HTML embed
*
* @since 4.4.0
* @output wp-includes/js/wp-embed.js
*
* This file cannot have ampersands in it. This is to ensure
* it can be embedded in older versions of WordPress.
* See https://core.trac.wordpress.org/changeset/35708.
*/
(function ( window, document ) {
'use strict';
var supportedBrowser = false,
loaded = false;
if ( document.querySelector ) {
if ( window.addEventListener ) {
supportedBrowser = true;
}
}
/** @namespace wp */
window.wp = window.wp || {};
if ( !! window.wp.receiveEmbedMessage ) {
return;
}
window.wp.receiveEmbedMessage = function( e ) {
var data = e.data;
if ( ! data ) {
return;
}
if ( ! ( data.secret || data.message || data.value ) ) {
return;
}
if ( /[^a-zA-Z0-9]/.test( data.secret ) ) {
return;
}
var iframes = document.querySelectorAll( 'iframe[data-secret="' + data.secret + '"]' ),
blockquotes = document.querySelectorAll( 'blockquote[data-secret="' + data.secret + '"]' ),
i, source, height, sourceURL, targetURL;
for ( i = 0; i < blockquotes.length; i++ ) {
blockquotes[ i ].style.display = 'none';
}
for ( i = 0; i < iframes.length; i++ ) {
source = iframes[ i ];
if ( e.source !== source.contentWindow ) {
continue;
}
source.removeAttribute( 'style' );
/* Resize the iframe on request. */
if ( 'height' === data.message ) {
height = parseInt( data.value, 10 );
if ( height > 1000 ) {
height = 1000;
} else if ( ~~height < 200 ) {
height = 200;
}
source.height = height;
}
/* Link to a specific URL on request. */
if ( 'link' === data.message ) {
sourceURL = document.createElement( 'a' );
targetURL = document.createElement( 'a' );
sourceURL.href = source.getAttribute( 'src' );
targetURL.href = data.value;
/* Only continue if link hostname matches iframe's hostname. */
if ( targetURL.host === sourceURL.host ) {
if ( document.activeElement === source ) {
window.top.location.href = data.value;
}
}
}
}
};
function onLoad() {
if ( loaded ) {
return;
}
loaded = true;
var isIE10 = -1 !== navigator.appVersion.indexOf( 'MSIE 10' ),
isIE11 = !!navigator.userAgent.match( /Trident.*rv:11\./ ),
iframes = document.querySelectorAll( 'iframe.wp-embedded-content' ),
iframeClone, i, source, secret;
for ( i = 0; i < iframes.length; i++ ) {
source = iframes[ i ];
if ( ! source.getAttribute( 'data-secret' ) ) {
/* Add secret to iframe */
secret = Math.random().toString( 36 ).substr( 2, 10 );
source.src += '#?secret=' + secret;
source.setAttribute( 'data-secret', secret );
}
/* Remove security attribute from iframes in IE10 and IE11. */
if ( ( isIE10 || isIE11 ) ) {
iframeClone = source.cloneNode( true );
iframeClone.removeAttribute( 'security' );
source.parentNode.replaceChild( iframeClone, source );
}
}
}
if ( supportedBrowser ) {
window.addEventListener( 'message', window.wp.receiveEmbedMessage, false );
document.addEventListener( 'DOMContentLoaded', onLoad, false );
window.addEventListener( 'load', onLoad, false );
}
})( window, document );
//--><!]]>
</script><iframe sandbox="allow-scripts" security="restricted" src="https://sydneygi.com.au/whole-genomes-redefine-mutational-landscape-pancreatic-cancer/embed/" width="600" height="338" title="“Whole genomes redefine the mutational landscape of pancreatic cancer.” — Sydney Gastroenterology" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe>Abstract Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal adenocarcinomas (PDACs). Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) […]